Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias.
نویسندگان
چکیده
a,c,d , b c,d * Jeffrey E. Saffitz , Richard B. Schuessler , Kathryn A. Yamada Department of Pathology, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St. Louis, MO, 63110, USA Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA
منابع مشابه
The Different Mechanisms of Action Potential Propagation in the Heart
It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...
متن کاملThe Different Mechanisms of Action Potential Propagation in the Heart
It was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. Some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (AP). It seems that some other types of mechanisms must be involved in AP propagation. In this article, we...
متن کاملEffects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes.
OBJECTIVES To elucidate signal transduction pathways regulating expression of myocardial gap junction channel proteins (connexins) and to determine whether mediators of cardiac hypertrophy might promote remodeling of gap junctions, we characterized the effects of angiotensin II on expression of the major cardiac gap junction protein connexin43 (Cx43) in cultured neonatal rat ventricular myocyte...
متن کاملMyocardial gap junctions: targets for novel approaches in the prevention of life-threatening cardiac arrhythmias.
Direct cell-to-cell communication in the heart is maintained via gap junction channels composed of proteins termed connexins. Connexin channels ensure molecular and electrical signals propagation and hence are crucial in myocardial synchronization and heart function. Disease-induced gap junctions remodeling and/or an impairment or even block of intercellular communication due to acute pathologi...
متن کاملRegulation of intercellular coupling in acute and chronic heart disease.
Effective pump function of the heart depends on the precise control of spatial and temporal patterns of electrical activation. Accordingly, the distribution and function of gap junction channels are important determinants of the conduction properties of myocardium and undoubtedly play other roles in intercellular communication crucial to normal cardiac function. Recent advances have begun to el...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cardiovascular research
دوره 42 2 شماره
صفحات -
تاریخ انتشار 1999